Commentary
Gradov Oleg V CHEMBIO Department, N.N. Semenov Federal Research Centre For Chemical Physics Of The Russian Academy Of Sciences (FRC CP RAS), Moscow, Kosygina 4, 119991, Russia
Recieved on: 2024-11-01, Accepted on: 2024-12-04, Published on: 2024-12-11
The history of MS-patch-clamp technique development as integration of single-cell mass spectrometric and membrane electrophysiological instrumental approaches (from the integration of patch-clamp electrophysiology and capillary electrophoresis-mass spectrometry and primary MS-patch-clamp proposals to the novel single-lysosome mass spectrometry techniques (SLMS) and rapidly progressing area of combined single-cell-level mass-spectrometry and capillary electrophoresis for the analysis of activity of excitable living tissues) has been considered. The author expresses a desire for international collaborations to advance the development of MS patch clamp methods and related techniques in the future. The material of this short communication was initially planned as a presentation at the conference on mass spectrometry in 2024, but the inability to obtain a visa from Russia and financial difficulties associated with the international sanctions made this presentation impossible.