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Research Article

Solid-State Study of Rifaximin in Organic Solvents

M. Ángeles Peña

M. Buhagiar

N. Borg

Recieved on: 2023-03-08, Accepted on: 2023-05-05, Published on: 2023-06-12

Abstract

The objective of this paper was to study the behavior of rifaximin crystals obtained by solvent evaporation crystallization processes. The solid phases obtained were characterized and studied by thermal analysis and infrared spectroscopy. These studies are very important to know and analyses the polymorphic forms of drugs. From the results, all possible polymorphic forms can be identified and the most suitable one chosen according to its dissolution rate and bioavailability.

Keywords

Rifaximin; Thermal analysis; Polymorphism; physicochemical properties